:root{font-family:Inter,ui-sans-serif,-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif;color-scheme:light;--bg:#f4f7fb;--surface:#fff;--surface2:#f8fafc;--surface3:#edf2f7;--text:#142033;--muted:#6c798b;--line:#dfe6ee;--accent:#3157d5;--accent2:#2447bb;--accent-soft:#e9eeff;--green:#11845b;--green-soft:#e7f7f0;--amber:#99650a;--amber-soft:#fff3d6;--red:#b64242;--red-soft:#fff0f0;--shadow:0 10px 35px rgba(31,43,61,.08);--shadow-sm:0 4px 18px rgba(31,43,61,.06);--radius:18px}
:root[data-theme="dark"]{color-scheme:dark;--bg:#09111e;--surface:#0f1a2a;--surface2:#121f31;--surface3:#17263a;--text:#e8eef7;--muted:#96a5b8;--line:#24354b;--accent:#819cff;--accent2:#a3b4ff;--accent-soft:#1a2953;--green:#4bd0a0;--green-soft:#14392f;--amber:#e4b14f;--amber-soft:#3a2a12;--red:#f08080;--red-soft:#3d1d22;--shadow:0 12px 35px rgba(0,0,0,.28);--shadow-sm:0 6px 20px rgba(0,0,0,.2)}
*{box-sizing:border-box}html,body{margin:0;min-height:100%;background:var(--bg);color:var(--text)}button,input,select{font:inherit}button{cursor:pointer}button:disabled{opacity:.45;cursor:not-allowed}a{color:var(--accent);text-decoration:none}a:hover{text-decoration:underline}.topbar{height:70px;position:sticky;top:0;z-index:20;background:color-mix(in srgb,var(--surface) 92%,transparent);backdrop-filter:blur(18px);border-bottom:1px solid var(--line);display:grid;grid-template-columns:250px 1fr auto;align-items:center;padding:0 24px}.brand{border:0;background:transparent;color:var(--text);display:flex;gap:11px;align-items:center;text-align:left}.brand-mark{width:38px;height:38px;border-radius:12px;display:grid;place-items:center;box-shadow:0 8px 20px rgba(11,18,32,.18);overflow:hidden}.brand-logo{display:block;width:38px;height:38px}.brand strong{display:block;font-size:17px}.brand small{display:block;color:var(--muted);font-size:11px;margin-top:2px}.nav-tabs{display:flex;justify-content:center;gap:4px}.nav-tabs button{border:0;background:transparent;color:var(--muted);display:flex;gap:7px;align-items:center;padding:9px 13px;border-radius:10px;font-size:13px;font-weight:700}.nav-tabs button.active{background:var(--accent-soft);color:var(--accent)}.top-actions{display:flex;gap:8px;align-items:center}.privacy-pill{display:flex;gap:6px;align-items:center;background:var(--green-soft);color:var(--green);padding:8px 10px;border-radius:999px;font-size:12px;font-weight:750}.icon-btn{width:37px;height:37px;border:1px solid var(--line);background:var(--surface);color:var(--muted);border-radius:10px;display:grid;place-items:center}.icon-btn:hover{background:var(--surface2);color:var(--text)}.main{width:100%;max-width:1440px;margin:0 auto;padding:38px 42px 70px}.page{display:flex;flex-direction:column;gap:22px}.import-page{max-width:1120px;margin:0 auto}.hero{text-align:center;padding:28px 12% 4px}.eyebrow{color:var(--accent);font-size:12px;text-transform:uppercase;letter-spacing:.1em;font-weight:800}.eyebrow.success{color:var(--green)}.hero h1,.page-title h1{font-size:clamp(34px,5vw,58px);letter-spacing:-.045em;line-height:1.02;margin:12px 0 16px}.hero h1 span{color:var(--accent)}.hero p,.page-title p{color:var(--muted);font-size:17px;line-height:1.65;margin:0 auto;max-width:820px}.hero-chips{display:flex;justify-content:center;gap:9px;flex-wrap:wrap;margin-top:20px}.hero-chips span{color:var(--muted);background:var(--surface);border:1px solid var(--line);padding:7px 10px;border-radius:999px;font-size:12px}.dropzone{margin-top:12px;background:var(--surface);border:1.5px dashed color-mix(in srgb,var(--accent) 35%,var(--line));border-radius:24px;padding:42px;text-align:center;box-shadow:var(--shadow-sm);transition:.2s}.dropzone.drag{border-color:var(--accent);background:var(--accent-soft);transform:translateY(-2px)}.drop-icon{width:60px;height:60px;border-radius:18px;background:var(--accent-soft);display:grid;place-items:center;color:var(--accent);margin:0 auto 16px}.dropzone h2{margin:0 0 7px;font-size:22px}.dropzone>p{color:var(--muted);margin:0 0 18px}.primary,.secondary{border:0;border-radius:11px;padding:11px 16px;font-weight:750;display:inline-flex;gap:8px;align-items:center;justify-content:center}.primary{background:var(--accent);color:white;box-shadow:0 7px 18px color-mix(in srgb,var(--accent) 25%,transparent)}.primary:hover{background:var(--accent2)}.secondary{background:var(--surface2);border:1px solid var(--line);color:var(--text)}.primary.large{padding:14px 19px}.local-note{margin:22px auto 0;padding-top:18px;border-top:1px solid var(--line);color:var(--muted);max-width:580px;font-size:12px;display:flex;gap:8px;align-items:center;justify-content:center}.card{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);box-shadow:var(--shadow-sm);padding:22px}.section-head{display:flex;justify-content:space-between;align-items:flex-start;gap:20px}.section-head h2,.card h2{margin:5px 0 0;font-size:21px;letter-spacing:-.02em}.kicker{color:var(--muted);font-size:11px;text-transform:uppercase;letter-spacing:.11em;font-weight:800}.metrics{display:grid;grid-template-columns:repeat(6,1fr);gap:10px}.metrics.compact{grid-template-columns:repeat(4,1fr);margin:24px 0}.metric{background:var(--surface);border:1px solid var(--line);border-radius:14px;padding:17px 18px}.card .metric{background:var(--surface2)}.metric strong{font-size:22px;display:block}.metric span{display:block;color:var(--muted);font-size:11px;margin-top:5px}.metric.warn strong{color:var(--amber)}.detections{display:grid;gap:8px}.detection{border:1px solid var(--line);background:var(--surface2);border-radius:13px;padding:12px 13px;display:grid;grid-template-columns:auto 1fr auto;gap:11px;align-items:center}.file-dot{width:34px;height:34px;display:grid;place-items:center;border-radius:9px;background:var(--surface3);color:var(--muted)}.detection strong{font-size:13px}.detection span:not(.confidence){display:block;color:var(--muted);font-size:11px;margin-top:3px}.confidence{font-size:10px;font-weight:800;text-transform:uppercase;letter-spacing:.06em;padding:6px 8px;border-radius:999px}.confidence.good{color:var(--green);background:var(--green-soft)}.confidence.warn{color:var(--amber);background:var(--amber-soft)}.row{display:flex;gap:10px}.row.end{justify-content:flex-end;margin-top:18px}.format-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:14px}.format-card{background:var(--surface);border:1px solid var(--line);border-radius:16px;padding:20px}.format-card>span{color:var(--accent);display:block;margin-bottom:12px}.format-card h3{font-size:15px;margin:0 0 7px}.format-card p{font-size:12px;color:var(--muted);line-height:1.6;margin:0}.disclaimer,.analysis-note,.alert{display:flex;gap:12px;align-items:flex-start;border-radius:14px;padding:15px 17px;font-size:12px}.disclaimer{background:var(--surface3);color:var(--muted);flex-direction:column;gap:3px}.disclaimer strong{color:var(--text)}.alert.error{background:var(--red-soft);color:var(--red);border:1px solid color-mix(in srgb,var(--red) 20%,transparent);flex-direction:column}.alert span{color:var(--text)}.inline-warning{color:var(--amber);font-size:12px;margin-top:10px}.settings-panel{margin:18px 0 5px;border:1px solid var(--line);background:var(--surface2);border-radius:14px;padding:17px}.settings-grid{display:grid;grid-template-columns:1fr 1fr;gap:12px}.settings-panel label>span,.explore-controls 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var(--line);display:grid;grid-template-columns:minmax(260px,1fr) 180px 220px auto;gap:9px}.search{display:flex;align-items:center;border:1px solid var(--line);border-radius:10px;background:var(--surface2);padding:0 10px;color:var(--muted)}.search input{border:0;outline:0;background:transparent;color:var(--text);width:100%;padding:10px 0}.segmented{display:flex;background:var(--surface2);border:1px solid var(--line);border-radius:10px;padding:3px}.segmented button{border:0;background:transparent;color:var(--muted);border-radius:7px;padding:6px 9px;font-size:11px;font-weight:700}.segmented button.active{background:var(--surface);color:var(--text);box-shadow:var(--shadow-sm)}.table-meta{padding:9px 14px;background:var(--surface2);display:flex;justify-content:space-between;color:var(--muted);font-size:10px}.table-wrap{overflow:auto;max-height:620px}table{border-collapse:collapse;width:100%;font-size:12px}thead th{position:sticky;top:0;background:var(--surface);z-index:2;text-align:left;color:var(--muted);font-size:10px;text-transform:uppercase;letter-spacing:.05em;padding:10px 12px;border-bottom:1px solid var(--line)}tbody td{padding:11px 12px;border-bottom:1px solid var(--line);vertical-align:top;white-space:nowrap}tbody tr:hover{background:var(--surface2)}td small{display:block;color:var(--muted);font-size:9px;margin-top:3px}.mono{font-family:ui-monospace,SFMono-Regular,Menlo,monospace}.muted{color:var(--muted)}.tag{display:inline-flex;margin-left:6px;padding:3px 6px;border-radius:999px;font-size:9px;font-weight:800}.tag.subtle{background:var(--surface3);color:var(--muted)}.tag.abnormal,.result.flagged{color:var(--red)}.tag.abnormal{background:var(--red-soft)}.issue{color:var(--amber);font-weight:800}.ok{color:var(--green);font-size:10px}.source{color:var(--muted)}.table-limit{text-align:center;color:var(--muted);font-size:11px;padding:10px}.analysis-note{background:var(--amber-soft);color:var(--amber);border:1px solid color-mix(in srgb,var(--amber) 20%,transparent)}.explore-controls{display:grid;grid-template-columns:1fr 1fr;gap:12px}.explore-grid{display:grid;grid-template-columns:2fr 1fr;gap:14px}.chart-card{min-height:430px}.unit-badge{background:var(--surface2);border:1px solid var(--line);padding:6px 8px;border-radius:999px;color:var(--muted);font-size:10px}.chart{margin-top:22px}.chart svg{width:100%;height:auto}.gridline{stroke:var(--line);stroke-width:1}.axis-label{fill:var(--muted);font-size:11px}.line{stroke:var(--accent);stroke-width:3;stroke-linecap:round;stroke-linejoin:round}.point{fill:var(--surface);stroke:var(--accent);stroke-width:3}.point.flagged{stroke:var(--red)}.empty-chart{min-height:310px;display:grid;place-items:center;align-content:center;text-align:center;color:var(--muted);gap:8px}.empty-chart strong{color:var(--text)}.empty-chart span{font-size:12px}.bars{display:grid;gap:13px;margin-top:24px}.bar-row{display:grid;grid-template-columns:minmax(100px,1.2fr) 1fr auto;align-items:center;gap:9px;font-size:11px}.bar-row>span{white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.bar-row>div{height:7px;background:var(--surface3);border-radius:99px;overflow:hidden}.bar-row i{height:100%;display:block;background:var(--accent);border-radius:99px}.bar-row strong{font-size:10px}.export-grid{display:grid;grid-template-columns:1.4fr 1fr;gap:14px}.export-options{display:grid;gap:9px;margin-top:15px}.export-choice{width:100%;text-align:left;border:1px solid var(--line);background:var(--surface2);color:var(--text);border-radius:13px;padding:13px;display:flex;gap:12px}.export-choice.active{border-color:var(--accent);background:var(--accent-soft)}.radio{width:21px;height:21px;border-radius:50%;border:1.5px solid var(--line);display:grid;place-items:center;flex:0 0 auto}.export-choice.active .radio{background:var(--accent);border-color:var(--accent);color:white}.export-choice strong{font-size:13px;display:flex;gap:8px;align-items:center}.export-choice em{font-style:normal;font-size:9px;text-transform:uppercase;color:var(--accent);background:var(--surface);padding:3px 5px;border-radius:99px}.export-choice small{display:block;color:var(--muted);line-height:1.5;margin-top:3px}.export-summary>.search{margin-top:15px}.export-stats{display:grid;grid-template-columns:repeat(3,1fr);gap:8px;margin:14px 0}.export-stats div{background:var(--surface2);padding:13px;border-radius:12px}.export-stats strong{display:block;font-size:19px}.export-stats span{display:block;color:var(--muted);font-size:9px;margin-top:3px}.privacy-box{display:flex;gap:10px;align-items:flex-start;background:var(--green-soft);color:var(--green);border-radius:12px;padding:13px}.privacy-box strong,.privacy-box span{display:block}.privacy-box span{color:var(--text);opacity:.8;font-size:10px;margin-top:2px;line-height:1.4}.column-picker{display:grid;grid-template-columns:repeat(4,1fr);gap:8px;margin-top:15px}.column-picker label{display:flex;align-items:center;gap:8px;background:var(--surface2);border:1px solid var(--line);border-radius:9px;padding:9px;font-size:11px}.final-export{display:flex;justify-content:space-between;align-items:center;gap:20px}.final-export p{color:var(--muted);font-size:12px;margin:6px 0 0}.about-layout{display:grid;grid-template-columns:230px 1fr;gap:16px;align-items:start}.about-nav{display:grid;gap:5px;position:sticky;top:92px}.about-nav button{border:0;background:transparent;color:var(--muted);padding:10px 12px;border-radius:9px;text-align:left;font-size:12px}.about-nav button.active{background:var(--accent-soft);color:var(--accent);font-weight:800}.manual{padding:34px 40px;min-height:520px}.manual>h2{font-size:28px;margin:0 0 15px}.manual h3{font-size:15px;margin:22px 0 6px}.manual p,.manual li{color:var(--muted);line-height:1.75;font-size:13px}.manual code{background:var(--surface3);padding:2px 5px;border-radius:5px;color:var(--text)}.manual-icon{width:50px;height:50px;background:linear-gradient(145deg,#ef6262,#c93c63);color:white;border-radius:15px;display:grid;place-items:center;margin-bottom:18px}.credit{margin-top:30px;border-top:1px solid var(--line);padding-top:18px;display:flex;justify-content:space-between;align-items:center}.credit span{color:var(--muted);font-size:11px}.credit a{font-weight:800}.manual-step{display:grid;grid-template-columns:44px 1fr;gap:14px;padding:16px 0;border-top:1px solid var(--line)}.manual-step>span{width:35px;height:35px;border-radius:10px;display:grid;place-items:center;background:var(--accent-soft);color:var(--accent);font-size:10px;font-weight:900}.manual-step h3{margin:0}.manual-step p{margin:4px 0 0}.note{background:var(--surface2);padding:13px;border-radius:12px;color:var(--muted);font-size:11px}.big-warning{display:flex;flex-direction:column;gap:4px;background:var(--red-soft);color:var(--red);border-radius:13px;padding:16px;margin:12px 0 20px}.big-warning span{color:var(--text);font-size:11px;line-height:1.5}footer{border-top:1px solid var(--line);padding:15px 28px;color:var(--muted);font-size:10px;display:flex;justify-content:space-between;background:var(--surface)}
@media(max-width:1100px){.topbar{grid-template-columns:210px 1fr auto;padding:0 16px}.privacy-pill{display:none}.main{padding:28px 24px 60px}.metrics{grid-template-columns:repeat(3,1fr)}.toolbar{grid-template-columns:1fr 1fr}.segmented{grid-column:span 2}.mapping-grid,.column-picker{grid-template-columns:repeat(2,1fr)}}
@media(max-width:760px){.topbar{height:auto;grid-template-columns:1fr auto;padding:10px 12px}.brand small{display:none}.nav-tabs{grid-column:1/-1;grid-row:2;overflow:auto;justify-content:flex-start;padding-top:8px}.nav-tabs button{white-space:nowrap}.main{padding:22px 14px 50px}.hero{padding:10px 0}.hero h1{font-size:38px}.hero p{font-size:14px}.dropzone{padding:28px 16px}.format-grid,.explore-grid,.export-grid,.about-layout,.settings-grid,.explore-controls{grid-template-columns:1fr}.metrics,.metrics.compact{grid-template-columns:repeat(2,1fr)}.toolbar{grid-template-columns:1fr}.segmented{grid-column:auto}.mapping-grid,.column-picker{grid-template-columns:1fr 1fr}.final-export{align-items:stretch;flex-direction:column}.about-nav{position:static;display:flex;overflow:auto}.about-nav button{white-space:nowrap}.manual{padding:24px 20px}.table-meta{gap:10px;flex-direction:column}.section-head{flex-direction:column}footer{flex-direction:column;gap:5px}}
@media(max-width:460px){.mapping-grid,.column-picker,.metrics,.metrics.compact{grid-template-columns:1fr}.hero-chips{gap:5px}.hero-chips span{font-size:10px}}
/* BloodsMD v2 research workbench */
.explore-v2{max-width:1600px;margin:0 auto}.analysis-shell{display:grid;grid-template-columns:235px minmax(0,1fr);gap:16px;align-items:start}.analysis-sidebar{position:sticky;top:92px;display:grid;gap:14px}.analysis-modules,.history-block{background:var(--surface);border:1px solid var(--line);border-radius:16px;box-shadow:var(--shadow-sm);padding:8px}.analysis-modules{display:grid;gap:3px}.analysis-modules button{border:0;background:transparent;color:var(--muted);padding:10px 11px;border-radius:10px;text-align:left;display:flex;justify-content:space-between;gap:10px;align-items:center}.analysis-modules button span{font-size:12px;font-weight:750}.analysis-modules button small{font-size:9px;color:var(--muted)}.analysis-modules button.active{background:var(--accent-soft);color:var(--accent)}.analysis-modules button.active small{color:var(--accent)}.history-block{padding:12px}.history-head{display:flex;justify-content:space-between;align-items:center;margin-bottom:9px}.history-head strong{font-size:11px;text-transform:uppercase;letter-spacing:.08em}.history-head span{background:var(--surface3);color:var(--muted);font-size:9px;border-radius:999px;padding:3px 7px}.history-block>p{font-size:10px;color:var(--muted);line-height:1.5;margin:8px 0 12px}.history-list{display:grid;gap:6px;max-height:260px;overflow:auto;margin-bottom:10px}.history-item{display:grid;grid-template-columns:1fr auto;border:1px solid var(--line);background:var(--surface2);border-radius:9px;overflow:hidden}.history-item>button:first-child{border:0;background:transparent;color:var(--text);text-align:left;padding:8px;min-width:0}.history-item strong,.history-item small{display:block;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.history-item strong{font-size:10px}.history-item small{font-size:8px;color:var(--muted);margin-top:3px}.history-delete{border:0;border-left:1px solid var(--line);background:transparent;color:var(--muted);padding:0 8px}.history-delete:hover{color:var(--red);background:var(--red-soft)}.secondary.small{width:100%;padding:8px 10px;font-size:10px}.analysis-main{min-width:0;display:grid;gap:14px}.analysis-toolbar{background:var(--surface);border:1px solid var(--line);border-radius:16px;padding:18px 20px;display:flex;justify-content:space-between;gap:16px;align-items:center;box-shadow:var(--shadow-sm)}.analysis-toolbar h2{font-size:24px;margin:4px 0 4px}.analysis-toolbar p{color:var(--muted);font-size:11px;line-height:1.5;margin:0}.analysis-controls{background:var(--surface);border:1px solid var(--line);border-radius:14px;padding:12px;display:grid;grid-template-columns:repeat(3,minmax(150px,1fr));gap:10px}.analysis-controls label>span{display:block;color:var(--muted);font-size:10px;font-weight:800;margin-bottom:6px}.analysis-controls select,.analysis-controls input{width:100%;border:1px solid var(--line);border-radius:9px;background:var(--surface2);color:var(--text);padding:9px}.analysis-controls label small{display:block;color:var(--muted);font-size:9px;margin-top:5px}.compact-control{grid-template-columns:minmax(220px,420px)}.analysis-grid{display:grid;gap:14px}.analysis-grid.two{grid-template-columns:1fr 1fr}.analysis-grid.three{grid-template-columns:repeat(3,1fr)}.chart-card-small{min-height:350px}.stat-table{display:grid;margin-top:14px;border-top:1px solid var(--line)}.stat-table>div{display:flex;justify-content:space-between;gap:20px;padding:10px 2px;border-bottom:1px solid var(--line);align-items:start}.stat-table span{color:var(--muted);font-size:11px}.stat-table strong{font-size:11px;text-align:right;max-width:60%;overflow-wrap:anywhere}.method-note{font-size:11px;color:var(--muted);line-height:1.65;margin:8px 0}.card.method-note{margin:0}.histbar{fill:var(--accent);opacity:.78}.box-body{fill:var(--accent-soft);stroke:var(--accent);stroke-width:2}.box-whisker{stroke:var(--muted);stroke-width:2}.box-median{stroke:var(--accent);stroke-width:3}.outlier{fill:var(--surface);stroke:var(--amber);stroke-width:2}.reference-line{stroke:var(--muted);stroke-width:1.5;stroke-dasharray:6 5}.reg-line{stroke:var(--accent);stroke-width:2.5}.paired-line{stroke:var(--accent);stroke-width:1.3;opacity:.35}.trajectory{stroke-width:2;opacity:.48;fill:none!important}.trajectory-point{stroke-width:1;opacity:.7}.trajectory.t0{stroke:var(--accent)}.trajectory-point.t0{stroke:var(--accent);fill:var(--accent)}.trajectory.t1{stroke:var(--green)}.trajectory-point.t1{stroke:var(--green);fill:var(--green)}.trajectory.t2{stroke:var(--amber)}.trajectory-point.t2{stroke:var(--amber);fill:var(--amber)}.trajectory.t3{stroke:var(--red)}.trajectory-point.t3{stroke:var(--red);fill:var(--red)}.trajectory.t4{stroke:color-mix(in srgb,var(--accent) 55%,var(--green))}.trajectory-point.t4{stroke:color-mix(in srgb,var(--accent) 55%,var(--green));fill:color-mix(in srgb,var(--accent) 55%,var(--green))}.trajectory.t5{stroke:color-mix(in srgb,var(--red) 55%,var(--accent))}.trajectory-point.t5{stroke:color-mix(in srgb,var(--red) 55%,var(--accent));fill:color-mix(in srgb,var(--red) 55%,var(--accent))}.trajectory.t6{stroke:color-mix(in srgb,var(--amber) 55%,var(--green))}.trajectory-point.t6{stroke:color-mix(in srgb,var(--amber) 55%,var(--green));fill:color-mix(in srgb,var(--amber) 55%,var(--green))}.trajectory.t7{stroke:var(--muted)}.trajectory-point.t7{stroke:var(--muted);fill:var(--muted)}.result-callout{background:var(--accent-soft);border:1px solid color-mix(in srgb,var(--accent) 20%,var(--line));border-radius:14px;padding:18px;margin:15px 0}.result-callout strong{display:block;color:var(--accent);font-size:24px}.result-callout span{display:block;color:var(--muted);font-size:11px;margin-top:5px}.formula{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;background:var(--surface2);border:1px solid var(--line);border-radius:10px;padding:12px;font-size:12px;overflow:auto}.alert.warning{background:var(--amber-soft);color:var(--amber);border:1px solid color-mix(in srgb,var(--amber) 20%,transparent);flex-direction:column}.alert.warning span{color:var(--text)}.feature-row{display:grid;grid-template-columns:repeat(3,1fr);gap:10px;margin-top:15px}.feature-row>div{background:var(--surface2);border:1px solid var(--line);border-radius:12px;padding:14px}.feature-row strong,.feature-row span{display:block}.feature-row strong{font-size:12px}.feature-row span{font-size:10px;color:var(--muted);margin-top:4px;line-height:1.45}.project-warning{margin-top:12px;background:var(--amber-soft);color:var(--amber);padding:11px 13px;border-radius:10px;font-size:10px;line-height:1.5}.coverage-matrix{display:grid;grid-template-columns:minmax(80px,140px) repeat(var(--cols),minmax(12px,1fr));gap:3px;overflow:auto;align-items:center;margin-top:16px}.matrix-head{height:18px}.matrix-col{writing-mode:vertical-rl;transform:rotate(180deg);font-size:8px;color:var(--muted);height:48px;overflow:hidden;text-overflow:ellipsis}.matrix-patient{font-size:9px;color:var(--muted);white-space:nowrap;overflow:hidden;text-overflow:ellipsis;padding-right:4px}.matrix-cell{height:15px;border-radius:3px;border:1px solid var(--line)}.matrix-cell.present{background:var(--accent);border-color:var(--accent)}.matrix-cell.missing{background:var(--surface3)}
@media(max-width:1150px){.analysis-shell{grid-template-columns:200px minmax(0,1fr)}.analysis-grid.three{grid-template-columns:1fr 1fr}.analysis-grid.three>section:last-child{grid-column:1/-1}}
@media(max-width:850px){.analysis-shell{grid-template-columns:1fr}.analysis-sidebar{position:static}.analysis-modules{display:flex;overflow:auto}.analysis-modules button{min-width:125px;flex:0 0 auto}.history-block{display:none}.analysis-grid.two,.analysis-grid.three{grid-template-columns:1fr}.analysis-grid.three>section:last-child{grid-column:auto}.analysis-controls{grid-template-columns:1fr 1fr}.feature-row{grid-template-columns:1fr}.analysis-toolbar{align-items:flex-start}.analysis-toolbar h2{font-size:20px}}
@media(max-width:560px){.analysis-controls{grid-template-columns:1fr}.analysis-toolbar{flex-direction:column;align-items:stretch}.analysis-toolbar .secondary{width:100%}.coverage-matrix{grid-template-columns:minmax(70px,100px) repeat(var(--cols),14px)}}

/* Plot Studio v2.1 */
.plot-frame{position:relative}.plot-frame .chart{margin-top:22px}.plot-popout{position:absolute;top:2px;right:2px;border:1px solid var(--line);background:color-mix(in srgb,var(--surface) 94%,transparent);color:var(--muted);border-radius:9px;padding:7px 9px;font-size:10px;font-weight:800;display:flex;gap:5px;align-items:center;opacity:.78;transition:.16s;z-index:2}.plot-frame:hover .plot-popout,.plot-popout:focus{opacity:1;color:var(--accent);border-color:color-mix(in srgb,var(--accent) 35%,var(--line));background:var(--surface)}
.plot-studio-backdrop{position:fixed;inset:0;background:rgba(4,9,18,.72);backdrop-filter:blur(6px);z-index:100;display:grid;place-items:center;padding:22px}.plot-studio{width:min(1500px,97vw);height:min(920px,96vh);background:var(--surface);border:1px solid var(--line);border-radius:20px;box-shadow:0 35px 100px rgba(0,0,0,.36);display:grid;grid-template-rows:auto minmax(0,1fr) auto;overflow:hidden}.plot-studio-head{display:flex;justify-content:space-between;gap:20px;align-items:flex-start;padding:18px 22px;border-bottom:1px solid var(--line)}.plot-studio-head h2{font-size:22px;margin:4px 0}.plot-studio-head p{font-size:11px;color:var(--muted);margin:0}.plot-studio-body{display:grid;grid-template-columns:340px minmax(0,1fr);min-height:0}.plot-controls{border-right:1px solid var(--line);overflow:auto;padding:12px;background:var(--surface2)}.plot-controls details{background:var(--surface);border:1px solid var(--line);border-radius:12px;margin-bottom:9px;overflow:hidden}.plot-controls summary{font-size:11px;font-weight:850;padding:11px 12px;cursor:pointer;user-select:none}.plot-controls details>label,.plot-controls details>.control-grid,.plot-controls details>.axis-control-grid,.plot-controls details>.colour-grid,.plot-controls details>.preset-row,.plot-controls details>.check-row,.plot-controls details>.plot-help{margin-left:12px;margin-right:12px}.plot-controls label{display:block;margin-bottom:10px}.plot-controls label>span{display:block;color:var(--muted);font-size:9px;font-weight:800;margin-bottom:5px}.plot-controls input:not([type=checkbox]):not([type=color]),.plot-controls select{width:100%;border:1px solid var(--line);border-radius:8px;background:var(--surface2);color:var(--text);padding:8px 9px;font-size:11px}.plot-controls input[type=color]{width:100%;height:33px;padding:3px;border:1px solid var(--line);border-radius:8px;background:var(--surface2)}.plot-controls input[type=range]{padding:0;border:0;background:transparent}.plot-controls input:disabled{opacity:.4}.plot-controls label small{display:block;color:var(--muted);font-size:8px;margin-top:4px}.control-grid.two,.axis-control-grid,.colour-grid{display:grid;grid-template-columns:1fr 1fr;gap:8px}.colour-grid{grid-template-columns:repeat(3,1fr)}.check-row{display:flex!important;align-items:center;gap:8px;background:var(--surface2);border:1px solid var(--line);border-radius:8px;padding:8px!important}.check-row input{margin:0}.check-row span{margin:0!important}.preset-row{display:flex;gap:6px;flex-wrap:wrap;margin-bottom:12px}.preset-row button{border:1px solid var(--line);background:var(--surface2);color:var(--muted);border-radius:999px;padding:6px 8px;font-size:9px;font-weight:800}.preset-row button:hover{color:var(--accent);border-color:var(--accent)}.plot-help{font-size:9px;color:var(--muted);line-height:1.45;margin-top:0;margin-bottom:12px}.plot-preview{min-width:0;overflow:auto;padding:28px;background:color-mix(in srgb,var(--bg) 82%,var(--surface));display:grid;place-items:center}.plot-preview-sheet{width:min(100%,1100px);border-radius:8px;box-shadow:0 14px 44px rgba(0,0,0,.14);padding:28px;transition:.15s}.plot-preview-heading{padding:0 8px 8px}.plot-preview-title{font-weight:750;letter-spacing:-.02em;line-height:1.2}.plot-preview-subtitle{font-size:12px;opacity:.72;margin-top:5px}.plot-preview-svg svg{width:100%;height:auto;display:block}.plot-studio-foot{border-top:1px solid var(--line);padding:12px 18px;display:flex;justify-content:space-between;gap:12px;background:var(--surface)}.plot-studio-foot>div{display:flex;gap:8px;flex-wrap:wrap}
@media(max-width:900px){.plot-studio-backdrop{padding:0}.plot-studio{width:100vw;height:100vh;border-radius:0;border:0}.plot-studio-body{grid-template-columns:1fr;overflow:auto}.plot-controls{border-right:0;border-bottom:1px solid var(--line);max-height:45vh}.plot-preview{min-height:55vh}.plot-studio-foot{position:sticky;bottom:0}.plot-popout span{display:none}}
/* v2.2 flexible source-column mapper */
.import-core-grid{grid-template-columns:minmax(190px,1fr) minmax(150px,.7fr) minmax(260px,1.25fr)}
.source-preview{margin:18px 0;padding:16px;border:1px solid var(--line);border-radius:14px;background:var(--surface)}
.source-preview h3,.mapping-heading h3,.metadata-mapper h3{margin:0 0 5px;font-size:13px}
.source-preview>p,.mapping-heading p,.metadata-mapper>p{margin:0 0 12px;color:var(--muted);font-size:11px;line-height:1.55}
.source-column-grid{display:flex;gap:8px;overflow-x:auto;padding-bottom:6px}
.source-column{min-width:175px;max-width:240px;padding:10px;border:1px solid var(--line);border-radius:10px;background:var(--surface2)}
.source-column strong{display:block;font-size:11px;overflow-wrap:anywhere;margin-bottom:7px}
.source-column small{display:block;color:var(--muted);font-size:9px;white-space:nowrap;overflow:hidden;text-overflow:ellipsis;padding:2px 0}
.mapping-heading{display:flex;justify-content:space-between;align-items:flex-start;margin-top:18px}
.mapping-grid.detailed{grid-template-columns:repeat(3,minmax(0,1fr))}
.mapping-field>span{display:flex!important;justify-content:space-between;gap:8px;align-items:center}
.mapping-field em{font-style:normal;font-size:8px;text-transform:uppercase;letter-spacing:.06em;color:var(--muted);font-weight:800}
.mapping-field.required em{color:var(--accent)}
.mapping-field.required select{border-color:color-mix(in srgb,var(--accent) 35%,var(--line))}
.metadata-mapper{margin-top:18px;padding-top:16px;border-top:1px solid var(--line)}
.metadata-mapper h3 span{font-size:9px;color:var(--muted);font-weight:700;text-transform:uppercase;letter-spacing:.07em;margin-left:5px}
.metadata-options{display:flex;gap:7px;flex-wrap:wrap;max-height:180px;overflow:auto}
.metadata-options label{display:flex;gap:7px;align-items:center;border:1px solid var(--line);background:var(--surface);padding:7px 9px;border-radius:9px;font-size:10px;color:var(--muted)}
.metadata-options input{accent-color:var(--accent)}
@media(max-width:900px){.import-core-grid,.mapping-grid.detailed{grid-template-columns:1fr 1fr}}
@media(max-width:620px){.import-core-grid,.mapping-grid.detailed{grid-template-columns:1fr}.source-column{min-width:150px}}

/* v2.3 longitudinal smoothing controls */
.longitudinal-controls{grid-template-columns:repeat(auto-fit,minmax(190px,1fr))}.longitudinal-controls input[type=range]{padding:0;border:0;background:transparent}.longitudinal-controls small{line-height:1.35}

.coverage-list{max-height:560px;overflow:auto;padding-right:4px}.coverage-list .bar-row strong{min-width:74px;text-align:right}

/* v2.5 patient grouping, metadata joins and cohort analyses */
.group-mapper{margin-top:18px;padding:15px;border:1px solid color-mix(in srgb,var(--accent) 24%,var(--line));border-radius:13px;background:color-mix(in srgb,var(--accent-soft) 35%,var(--surface))}
.group-mapper h3{margin:0 0 5px;font-size:13px}.group-mapper h3 span,.metadata-mapper h3 span{font-size:9px;color:var(--muted);font-weight:600;margin-left:6px}.group-mapper>p{margin:0 0 12px;color:var(--muted);font-size:11px;line-height:1.55}
.patient-meta-card{margin-top:16px;padding:17px;border:1px solid var(--line);border-radius:14px;background:var(--surface2);display:grid;gap:14px}.patient-meta-card h3{margin:4px 0 4px;font-size:17px}.patient-meta-card p{margin:0;color:var(--muted);font-size:11px;line-height:1.55}.patient-meta-card>.section-head{align-items:center}.patient-meta-card .small{padding:7px 10px;font-size:10px}
.metadata-join-grid{display:grid;grid-template-columns:minmax(220px,.65fr) minmax(320px,1.35fr);gap:14px;align-items:start}.metadata-join-grid>label>span,.metadata-variable-list>span{display:block;color:var(--muted);font-size:10px;font-weight:800;margin-bottom:7px}.metadata-join-grid select{width:100%;border:1px solid var(--line);border-radius:9px;padding:9px;background:var(--surface);color:var(--text)}.metadata-variable-list>div{display:flex;flex-wrap:wrap;gap:6px}.metadata-variable-list label,.metadata-options label{display:flex!important;gap:6px;align-items:center;border:1px solid var(--line);background:var(--surface);border-radius:999px;padding:6px 9px;margin:0!important}.metadata-variable-list label span,.metadata-options label span{font-size:9px;color:var(--text);margin:0!important}.metadata-variable-list input,.metadata-options input{margin:0}
.patient-variable-summary{display:flex;gap:8px;align-items:center;flex-wrap:wrap;border-top:1px solid var(--line);padding-top:12px}.patient-variable-summary>strong{font-size:10px;text-transform:uppercase;letter-spacing:.08em;color:var(--muted)}.patient-variable-summary>span{font-size:9px;padding:5px 8px;border-radius:999px;background:var(--green-soft);color:var(--green);font-weight:700}.patient-variable-summary>em{font-style:normal;font-size:9px;color:var(--amber)}
.patient-variable-cards{display:grid;grid-template-columns:repeat(auto-fit,minmax(190px,1fr));gap:9px;margin-top:12px}.patient-variable-cards>div{border:1px solid var(--line);background:var(--surface2);border-radius:12px;padding:12px}.patient-variable-cards strong{display:block;font-size:12px}.patient-variable-cards span,.patient-variable-cards small,.patient-variable-cards em{display:block;margin-top:4px}.patient-variable-cards span{font-size:10px;color:var(--accent);font-weight:700}.patient-variable-cards small{font-size:9px;color:var(--muted)}.patient-variable-cards em{font-style:normal;font-size:9px;color:var(--muted);line-height:1.4}.patient-vars-review{padding:15px 18px}
.group-stat-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(190px,1fr));gap:10px;margin-top:14px}.group-stat-grid>div{border:1px solid var(--line);border-radius:12px;background:var(--surface2);padding:12px}.group-stat-grid strong{display:block;font-size:13px}.group-stat-grid>div>span{display:block;color:var(--muted);font-size:9px;margin:4px 0 10px}.group-stat-grid dl{display:grid;grid-template-columns:1fr auto;gap:5px 8px;margin:0;font-size:9px}.group-stat-grid dt{color:var(--muted)}.group-stat-grid dd{margin:0;font-weight:800}
@media(max-width:760px){.metadata-join-grid{grid-template-columns:1fr}.patient-meta-card>.section-head{align-items:flex-start;flex-direction:column}}

/* v2.6 install experience + statistical diagnostics */
.install-btn{border:1px solid color-mix(in srgb,var(--accent) 30%,var(--line));background:var(--accent-soft);color:var(--accent);border-radius:10px;padding:8px 11px;display:inline-flex;align-items:center;gap:7px;font-size:12px;font-weight:800}.install-btn:hover{background:color-mix(in srgb,var(--accent-soft) 72%,var(--surface));border-color:var(--accent)}
.install-backdrop{position:fixed;inset:0;z-index:130;background:rgba(4,9,18,.64);backdrop-filter:blur(6px);display:grid;place-items:center;padding:20px}.install-card{width:min(470px,94vw);position:relative;background:var(--surface);border:1px solid var(--line);border-radius:22px;padding:28px;box-shadow:0 28px 90px rgba(0,0,0,.3)}.install-card h2{margin:7px 0 10px;font-size:28px;letter-spacing:-.035em}.install-card>p{margin:0;color:var(--muted);font-size:13px;line-height:1.65}.install-close{position:absolute;right:14px;top:14px;font-size:21px;line-height:1}.install-brand{margin-bottom:18px}.install-brand .brand-logo{width:54px;height:54px}.install-instruction{margin:20px 0 0;background:var(--surface2);border:1px solid var(--line);border-radius:13px;padding:14px 15px}.install-instruction strong,.install-instruction span{display:block}.install-instruction strong{font-size:12px}.install-instruction span{color:var(--muted);font-size:11px;line-height:1.55;margin-top:4px}.local-note.compact{max-width:none;margin-top:15px;padding-top:13px;justify-content:flex-start;text-align:left}.install-card .row.end{margin-top:18px}
.group-stat-grid em{display:block;margin-top:10px;padding-top:8px;border-top:1px solid var(--line);font-style:normal;font-size:9px;color:var(--muted);line-height:1.4}.metric strong{overflow-wrap:anywhere}.analysis-controls select#groupTest,.analysis-controls select#pairedTest,.analysis-controls select#correlationTest{font-weight:700}
@media(max-width:900px){.install-btn span{display:none}.install-btn{width:37px;height:37px;padding:0;justify-content:center}.privacy-pill{display:none}}